PBS pH7.5, DTT 1mM, 0.5mM Zwittergent 3-14 and 10% Glycerol if refolding. PBS, Urea 8M if denaturing conditions
Form
liquid
Delivery condition
Dry Ice
Delivery lead time in business days
Europe: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition
Lipase protein is stored:
At 4°C for short term period (less than a week)
At -20°C or -80°C for long term period
Recommendations
It is important to avoid avoid freezing/thawing cycles
20-40% glycerol may be added to improve cryoprotection
Brand
ProteoGenix
Host species
Escherichia coli (E.coli)
Fragment Type
Partial
Protein Accession
YP_056770.1
Spec:Entrez GeneID
2932970
Spec:SwissProtID
Q6A601
NCBI Reference
YP_056770.1
Aliases /Synonyms
LIPASE, triacylglycerol lipase precursor
Reference
PX-P1121
Note
For research use only
Description of Lipase Protein/ Propionibacterium Acnes LIPASE Recombinant Protein
General information on Lipase Protein:
Propionibacterium acnes lipase is a protein secreted by the Propionibacterium acnes which is a gram-positive anaerobic bacterium. This lipase protein metabolizes sebum which in turn results into metabolites that are responsible for the human skin condition known as acne vulgaris. It is also believed that lipase overexpression increases follicular development. Propionibacterium acnes lipase protein acts on triglycerides to release free fatty acids. Among the fatty acids released, Palmitic acid stimulates the toll-like receptor 2-mediated inflammasome. The latter is associated with the release of interleukin-1, Th17 differenciation and interleukin-17-mediated keratinocyte proliferation. Oleic acid, another fatty acid released stimulates adhesion and keratinocyte proliferation in Propionibacterium acnes, also via the release of interleukin-1. Antifugal drug ketoconazole has been suggested to inhibit P.acnes lipase activity. However, the mechanism by which ketoconazole inhibits P.acnes lipase protein remains unknown.
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