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Diphtheria toxin

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100ug, 50ug
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Product nameDiphtheria toxin
Uniprot IDP00587
Uniprot linkhttp://www.uniprot.org/uniprot/P00587
Expression systemProkaryotic expression
SequenceMKKIWLALAGLVLAFSASAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEE EELEGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKEFYSTDNKYDAAGYSVDNENPLSGK AGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQA KALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNK TVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGI ADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAV SWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSP VYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKSKEASSYDYILGWEFGGGVPEH KKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEEEELEGSHHHHHH
Molecular weight76.35kDa
Purity estimated>60% by SDS-PAGE
BufferPBS, pH=7.5
Delivery conditionDry Ice
Delivery lead time in business daysEurope: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment TypeGly26-Ser560
Aliases /SynonymsNAD(+)--diphthamide ADP-ribosyltransferase
ReferencePX-P4480
NoteFor research use only

Description of Diphtheria toxin

General Information about Diphtheria toxin

Diphtheria toxin is a complete toxin catalyst and protein synthesis inhibitor of ADP-ribosylation of EF-2. Diphtheria toxin from Corynebacterium diphtheriae can inhibit protein synthesis by catalyzing the ADP-ribosylation of eukaryotic aminoacyltransferase II (EF-2). Diphtheria toxin is cell permeable and can be transported across the endosomal membrane in response to low pH3. Diphtheria toxin is synthesized and excreted as an enzyme and must undergo two covalent changes to be activated

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