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Cyclin-dependent kinase inhibitor 2A(CDKN2A)

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Product nameCyclin-dependent kinase inhibitor 2A(CDKN2A)
Uniprot IDP42771
Uniprot linkhttp://www.uniprot.org/uniprot/P42771
Expression systemProkaryotic expression
SequenceMGSHHHHHHSGMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAE PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAE GPSDIPD
Molecular weight17.74kDa
Purity estimated85% by SDS-PAGE
BufferPBS, pH7.5
Delivery conditionDry Ice
Delivery lead time in business daysEurope: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment Typefull length
Aliases /SynonymsCyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A
ReferencePX-P4534
NoteFor research use only

Description of Cyclin-dependent kinase inhibitor 2A(CDKN2A)

General Information about Cyclin-dependent kinase inhibitor 2A(CDKN2A)

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene on human chromosome 9 p21.3. By strongly interacting with CDK4 and CDK6, it acts as a negative regulator of normal cell proliferation. This inhibits their ability to interact with cyclin D and phosphorylate retinoblastoma proteins.

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