CD80 Recombinant Protein

Reference: PX-P4090-100
Size

100ug

Brand

Product type

Host Species

Origin Species

Description of CD80 Recombinant Protein

General information on CD80 Recombinant Protein:

Cluster of Differentiation 80, also known as B7-1, is a member of the cell surface immunoglobulin superfamily. It is expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. CD80 plays a fundamental but different role in the activation of T cells. B7-1 / CD80 and B7-2 / CD86 and its CD28 and CTLA4 receptors constitute one of the main co-stimulatory pathways that regulate the response of T and B cells. CD80 is mainly expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. Although CTLA-4 and CD28 can bind to the same ligand, CTLA-4 binds B7-1 and B7-2 with an affinity 20-100 times greater than CD28 and participates in the negative regulation of immune responses. Therefore, CD80 is considered a promising therapeutic target for autoimmune diseases and various types of cancer.

Product nameCD80 Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight45kDa
Purity estimated>90% by SDS-PAGE
BufferC-terminal His Tag
Delivery conditionDry Ice
Storage conditionStore at - 20? to -80?. It is recommended that the protein be aliquoted for optimal storage.
BrandProteoGenix
Host speciesMammalian cells
Fragment TypeMet1~Asn242
Aliases /SynonymsCD28LG, CD28LG1, LAB7
ReferencePX-P4090
NoteFor research use only

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