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Bapineuzumab Biosimilar – Anti-APP Abeta mAb – Research Grade

Reference:
Size

100ug, 1MG

Isotype

IgG1-nd

Brand

ProteoGenix

Product type

Primary Antibodies

Clonality

Monoclonal Antibody

Expression system

Mammalian cells

Applications

Elisa, WB

Product nameBapineuzumab Biosimilar - Anti-APP Abeta mAb - Research Grade
SourceCAS 648895-38-9
SpeciesHumanized
Expression systemMammalian cells
Purity>85%
BufferPBS buffer PH7.5
Delivery conditionBlue ice (+4°C)
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Delivery Time3-5 days if in stock; 3-5 weeks if production needed
Storage conditionstore at -80°C
BrandProteoGenix
Aliases /SynonymsBapineuzumab,AAB-001,APP Abeta,anti-APP Abeta
ReferencePX-TA1180
NoteFor research use only. Not suitable for human use.
IsotypeIgG1-nd
ClonalityMonoclonal Antibody

Description of Bapineuzumab Biosimilar - Anti-APP Abeta mAb - Research Grade

Introduction to Bapineuzumab Biosimilar – Anti-APP Abeta mAb – Research Grade Bapineuzumab Biosimilar – Anti-APP Abeta mAb – Research Grade is a monoclonal antibody that has been developed as a potential treatment for Alzheimer’s disease. This biosimilar is designed to target amyloid-beta (Abeta) protein, which is believed to play a crucial role in the development and progression of Alzheimer’s disease. In this article, we will provide a detailed description of the structure, activity, and potential applications of Bapineuzumab Biosimilar.

Structure of Bapineuzumab Biosimilar

Bapineuzumab Biosimilar is a monoclonal antibody that is produced by recombinant DNA technology. It is a humanized antibody, meaning that it is derived from non-human sources but has been modified to resemble a human antibody. The antibody is composed of two identical heavy chains and two identical light chains, which are linked together by disulfide bonds. The heavy and light chains contain variable regions that are responsible for binding to the target protein, Abeta.

Activity of Bapineuzumab Biosimilar

Bapineuzumab Biosimilar works by binding to and neutralizing Abeta protein, which is known to form toxic plaques in the brains of Alzheimer’s patients. These plaques are believed to contribute to the cognitive decline and memory loss associated with the disease. By targeting and binding to Abeta, Bapineuzumab Biosimilar prevents the formation of these plaques and may slow down the progression of Alzheimer’s disease.

In addition to targeting Abeta, Bapineuzumab Biosimilar also has an immunomodulatory effect. It has been shown to activate the immune system and stimulate the production of anti-inflammatory cytokines, which may help to reduce inflammation in the brain. This is important as chronic inflammation has been linked to the development of Alzheimer’s disease.

Potential Applications of Bapineuzumab Biosimilar

Bapineuzumab Biosimilar is currently being investigated as a potential treatment for Alzheimer’s disease. It is believed that by targeting Abeta, this biosimilar may slow down the progression of the disease and improve cognitive function in patients. Clinical trials have shown promising results, with some patients showing improvements in cognitive function and a reduction in the size of Abeta plaques.

Aside from its potential as a therapeutic treatment, Bapineuzumab Biosimilar also has potential applications in research. It can be used as a tool to study the role of Abeta in Alzheimer’s disease and to better understand the mechanisms of action of this biosimilar. Additionally, Bapineuzumab Biosimilar can be used to develop diagnostic tests for early detection of Alzheimer’s disease.

Conclusion

In conclusion, Bapineuzumab Biosimilar – Anti-APP Abeta mAb – Research Grade is a monoclonal antibody that has been developed as a potential treatment for Alzheimer’s disease. It works by targeting and neutralizing Abeta protein, which is believed to play a crucial role in the development and progression of the disease. This biosimilar has shown promising results in clinical trials and also has potential applications in research. With further studies and development, Bapineuzumab Biosimilar may offer a new treatment option for Alzheimer’s disease and contribute to a better understanding of this debilitating condition.

Publication

Blömeke, L., Rehn, F., Pils, M. et al. Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects. Commun Med 4, 262 (2024). https://doi.org/10.1038/s43856-024-00690-w

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