9-77 Biosimilar – Anti-IL-8 mAb – Research Grade

Description of 9-77 Biosimilar - Anti-IL-8 mAb - Research Grade

Title: Understanding the Structure and

Activity of 9-77 Biosimilar – Anti-IL-8 mAb for Targeted Therapy Introduction:

9-77 Biosimilar – Anti-IL-8 mAb is a novel biosimilar monoclonal antibody (mAb) that has been developed for targeted therapy in various inflammatory diseases. It is a research grade antibody that specifically targets and inhibits the activity of Interleukin-8 (IL-8), a pro-inflammatory cytokine involved in various diseases. In this article, we will delve into the structure, activity, and potential applications of 9-77 Biosimilar – Anti-IL-8 mAb.

Structure of 9-77 Biosimilar – Anti-IL-8 mAb:

9-77 Biosimilar – Anti-IL-8 mAb is a recombinant humanized IgG1 monoclonal antibody. It is composed of two heavy chains and two light chains, each with a molecular weight of approximately 50 kDa. The antibody has a typical Y-shaped structure with two antigen-binding fragments (Fab) and one crystallizable fragment (Fc). The Fab regions are responsible for binding to the target IL-8, while the Fc region plays a crucial role in mediating effector functions.

Activity of 9-77 Biosimilar – Anti-IL-8 mAb:

The primary function of 9-77 Biosimilar – Anti-IL-8 mAb is to inhibit the activity of IL-8. IL-8 is a chemokine that plays a crucial role in recruiting and activating immune cells at the site of inflammation. However, overproduction of IL-8 has been linked to various inflammatory diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. 9-77 Biosimilar – Anti-IL-8 mAb binds to IL-8 with high specificity and affinity, thereby blocking its interaction with its receptors on immune cells. This results in the suppression of inflammatory responses and provides therapeutic benefits in various diseases.

Potential Applications of 9-77 Biosimilar – Anti-IL-8 mAb:

9-77 Biosimilar – Anti-IL-8 mAb has shown promising results in pre-clinical studies and is being evaluated for potential clinical applications. Some of the potential therapeutic areas where this antibody may be useful include:

1. Rheumatoid Arthritis (RA): RA is a chronic inflammatory disease characterized by joint inflammation and destruction. IL-8 has been found to play a critical role in the pathogenesis of RA. 9-77 Biosimilar – Anti-IL-8 mAb has shown to reduce joint inflammation and prevent joint damage in animal models of RA.

2. Psoriasis: Psoriasis is a chronic skin disorder characterized by red, scaly patches on the skin. IL-8 has been implicated in the development and progression of psoriasis. 9-77 Biosimilar – Anti-IL-8 mAb has shown to improve skin lesions and reduce inflammation in animal models of psoriasis.

3. Inflammatory Bowel Disease (IBD): IBD is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn’s disease and ulcerative colitis. IL-8 has been linked to the pathogenesis of IBD. 9-77 Biosimilar – Anti-IL-8 mAb has shown to reduce intestinal inflammation and improve disease symptoms in animal models of IBD.

4. Other Inflammatory Diseases: IL-8 has also been implicated in other inflammatory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. 9-77 Biosimilar – Anti-IL-8 mAb has shown potential in reducing inflammation and improving disease outcomes in these conditions.

Conclusion:

In summary, 9-77 Biosimilar – Anti-IL-8 mAb is a promising research grade antibody that specifically targets IL-8 and has shown potential in the treatment of various inflammatory diseases. Its unique structure and high specificity make it a promising candidate for targeted therapy. Further clinical studies are needed to fully evaluate its safety and efficacy in humans, but the early results are promising.

SDS-PAGE for 9-77 Biosimilar - Anti-IL-8 mAb

9-77 Biosimilar - Anti-IL-8 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.