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Tregalizumab ELISA Kit

Reference: KPTX137
Brand

ProteoGenix

Product type

Elisa assay kits

Size

96T

Product nameTregalizumab ELISA Kit
Delivery conditionBlue ice (+4°)
Storage conditionThe stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
BrandProteoGenix
Size96T
ReferenceKPTX137
NoteFor research use only.
Sample typePlasma, Serum
ImmunogenTregalizumab

Description of Tregalizumab ELISA Kit

Introduction

Tregalizumab is a novel therapeutic antibody that has shown promising results in the treatment of autoimmune diseases. This antibody targets and modulates the activity of regulatory T cells (Tregs), a type of immune cell that plays a critical role in maintaining immune homeostasis and preventing autoimmunity.

Structure of Tregalizumab

Tregalizumab is a humanized monoclonal antibody, meaning it is derived from human cells and has been modified to enhance its therapeutic properties. It is composed of two identical heavy chains and two identical light chains, each containing a variable region and a constant region. The variable region is responsible for binding to its target, while the constant region mediates effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).

Activity of Tregalizumab

Tregalizumab specifically targets and binds to the alpha subunit of the interleukin-2 receptor (IL-2R?) on the surface of Tregs. This receptor is responsible for binding to the cytokine interleukin-2 (IL-2), which is essential for the survival and function of Tregs. By binding to IL-2R?, Tregalizumab blocks the binding of IL-2 and inhibits the activation and proliferation of Tregs. This leads to a decrease in the number and activity of Tregs, allowing for a more balanced immune response.
Moreover, Tregalizumab has been shown to have a dual mechanism of action. In addition to blocking IL-2 signaling, it also induces the depletion of Tregs through ADCC and CDC. This further reduces the suppressive activity of Tregs and allows for a more robust immune response against autoimmune cells.

Application of Tregalizumab

Tregalizumab is currently being evaluated in clinical trials for the treatment of various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. These diseases are characterized by an imbalance in the immune system, with an increase in pro-inflammatory cells and a decrease in Tregs. By targeting and depleting Tregs, Tregalizumab aims to restore this balance and alleviate the symptoms of these diseases.
Early clinical trials have shown promising results, with Tregalizumab demonstrating a favorable safety profile and significant improvements in disease activity and symptoms. In a phase II trial for rheumatoid arthritis, Tregalizumab was found to be well-tolerated and significantly reduced the signs and symptoms of the disease compared to placebo. In another phase II trial for systemic lupus erythematosus, Tregalizumab showed promising efficacy in reducing disease activity and improving patient-reported outcomes.

ELISA Kit for Tregalizumab

The Tregalizumab ELISA Kit is a diagnostic tool used to measure the concentration of Tregalizumab in patient samples. This kit utilizes the principle of enzyme-linked immunosorbent assay (ELISA) to detect and quantify Tregalizumab based on its binding to IL-2R?. It is a sensitive and reliable method for monitoring Tregalizumab levels in patients undergoing treatment and can aid in optimizing dosing and assessing treatment response.
In conclusion, Tregalizumab is a promising therapeutic antibody that targets and modulates the activity of Tregs in autoimmune diseases. Its unique mechanism of action and favorable safety profile make it a potential treatment option for patients with various autoimmune disorders. The development of the Tregalizumab ELISA Kit further supports its clinical application and may aid in the personalized management of patients receiving this therapy.

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