Recombinant Mouse NDP/Norrin Protein, N-His-SUMO

Description of Recombinant Mouse NDP/Norrin Protein, N-His-SUMO

Introduction

Recombinant Mouse NDP/Norrin Protein is a genetically engineered protein that is produced in laboratory settings using recombinant DNA technology. It is a crucial protein in the Wnt signaling pathway and plays a significant role in various biological processes such as cell proliferation, differentiation, and migration. In this article, we will discuss the structure, activity, and applications of Recombinant Mouse NDP/Norrin Protein.

Structure of Recombinant Mouse NDP/Norrin Protein

The Recombinant Mouse NDP/Norrin Protein is a 133 amino acid protein with a molecular weight of approximately 14.5 kDa. It is a member of the cystine knot family of proteins and consists of a signal peptide, a cysteine-rich domain, and a C-terminal region. The protein is highly conserved among different species, with 94% similarity between the mouse and human protein sequences.

Activity of Recombinant Mouse NDP/Norrin Protein

Recombinant Mouse NDP/Norrin Protein is a potent activator of the Wnt signaling pathway, which is essential for embryonic development and tissue homeostasis. It binds to Frizzled receptors and LRP5/6 co-receptors, leading to the stabilization and nuclear translocation of β-catenin. This, in turn, activates the transcription of Wnt target genes, resulting in various cellular responses.

Studies have shown that Recombinant Mouse NDP/Norrin Protein also has anti-apoptotic effects and promotes cell survival. It has been reported to protect retinal neurons from cell death and promote neuronal differentiation in the central nervous system. Additionally, it has been shown to stimulate angiogenesis and promote blood vessel formation, making it a potential therapeutic agent for various vascular diseases.

Applications of Recombinant Mouse NDP/Norrin Protein

Studying Wnt Signaling Pathway

Recombinant Mouse NDP/Norrin Protein is a valuable tool for studying the Wnt signaling pathway. Its ability to activate the pathway in a controlled manner allows researchers to investigate its role in different biological processes. It can also be used to study the interaction between different components of the pathway and identify potential therapeutic targets.

Neuroprotection

Recombinant Mouse NDP/Norrin Protein has shown promising results in protecting retinal neurons from cell death and promoting neuronal differentiation. This makes it a potential therapeutic agent for neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Angiogenesis

Recombinant Mouse NDP/Norrin Protein has been shown to stimulate angiogenesis and promote blood vessel formation. This makes it a potential treatment for conditions such as ischemic heart disease, stroke, and diabetic retinopathy.

Drug Development

The Wnt signaling pathway is involved in various diseases, and targeting it has become a promising approach in drug development. Recombinant Mouse NDP/Norrin Protein can be used to screen and identify potential drugs that can modulate the pathway and treat diseases associated with its dysregulation.

Antigen for Antibody Production

Recombinant Mouse NDP/Norrin Protein can be used as an antigen to produce antibodies against it. These antibodies can then be used in various research and diagnostic applications, such as Western blotting, ELISA, and immunohistochemistry.

Therapeutic Protein

Recombinant Mouse NDP/Norrin Protein has shown promising results in various pre-clinical studies and is being investigated as a potential therapeutic protein for various diseases. Its ability to activate the