Description of Recombinant Monkeypox virus/MPXV E8L Protein
General information on Recombinant Monkeypox Virus E8L Protein
Monkeypox Virus E8L Protein: Structure
Recombinant Monkeypox Virus E8L Protein is a single polypeptide chain of 559 amino acids. It contains two domains, an N-terminal domain of approximately 250 amino acids and a C-terminal domain of approximately 300 amino acids.
Monkeypox Virus E8L Protein:Activity
Recombinant Monkeypox Virus E8L Protein is a viral protein that is expressed on the surface of infected cells. It plays a role in the pathogenesis of monkeypox by binding to the host cell surface and mediating virus-cell interactions.
Application of this antigen
Recombinant Monkeypox Virus E8L Protein has potential applications in the development of vaccines and therapies against monkeypox. It is a promising drug target for the development of antiviral drugs and immunotherapies.
SDS-PAGE For Recombinant Monkeypox virus/MPXV E8L Protein
Recombinant Monkeypox virus/MPXV E8L Protein, on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue.
Anti-MPXV E8L Antibody (SAA0285) binds with E8L protein in ELISA assay
Immobilized Recombinant Monkeypox virus/MPXV E8L Protein (cat. No. PX-P6055) at 0.5µg/mL (100µL/well) can bind Monkeypox virus/MPXV E8L Monoclonal Antibody SAA0285 (cat. No. PTX18823) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 34.61M.
Publication
Daniel Stern, Rebecca Surtees, Fridolin Treindl et al. Differentiation between mpox infection and MVA immunization by a novel machine learning-supported serological multiplex assay, 09 August 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-4822502/v1]
MpoxPlex: a high-throughput and versatile multiplexed immunoassay for assessing and discriminating between IgG responses to Mpox infection and vaccination, Scott Jones, Bethany Hicks, Helen Callaby, Daniel Bailey, Claire Gordon, Tommy Rampling, Catherine Houlihan, Rachael Jones, Marcus Pond, Ravi Mehta, Deborah Wright, Clarissa Oeser, Simon Tonge, Ezra Linley, Cathy Rowe, Bassam Hallis, Ashley Otter, medRxiv 2024.06.03.24308186; doi: https://doi.org/10.1101/2024.06.03.24308186
Assessment of MpoxPlex, a high-throughput and multiplexed immunoassay: a diagnostic accuracy study, Jones, Scott et al., The Lancet Microbe, Volume 0, Issue 0, 100987
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