Recombinant Human TACR2 Protein, N-His-SUMO

Description of Recombinant Human TACR2 Protein, N-His-SUMO

Structure of Recombinant Human TACR2 Protein

The Recombinant Human TACR2 Protein is a synthetic version of the human TACR2 protein, also known as the neurokinin 2 receptor (NK2R). It is produced through recombinant DNA technology, where the gene encoding for TACR2 is inserted into a host cell, such as bacteria or yeast, and then expressed to produce the protein.

The protein has a molecular weight of approximately 46 kDa and is composed of 407 amino acids. It has a characteristic seven-transmembrane domain structure, which is common among G protein-coupled receptors (GPCRs). TACR2 also has an extracellular N-terminal domain and an intracellular C-terminal domain.

Activity of Recombinant Human TACR2 Protein

The main function of TACR2 is to bind to the neuropeptide substance P and mediate its effects, such as neurogenic inflammation, smooth muscle contraction, and pain perception. As a GPCR, TACR2 activates intracellular signaling pathways upon ligand binding.

Studies have shown that the recombinant TACR2 protein has similar activity to the natural form, with the ability to bind to substance P and activate downstream signaling pathways. This makes it a valuable tool for studying the role of TACR2 in various physiological and pathological processes.

Application of Recombinant Human TACR2 Protein

The recombinant TACR2 protein has a wide range of applications in both research and therapeutic settings. Here are some of its main uses:

• Drug Development: TACR2 is a potential target for the treatment of various diseases, including chronic pain, inflammation, and cancer. The recombinant protein can be used to screen and identify potential drug candidates that can modulate TACR2 activity.
• Neuroscience Research: TACR2 is highly expressed in the central and peripheral nervous systems, making it a key player in various neurological processes. The recombinant protein can be used to study the role of TACR2 in neuronal development, pain perception, and other neurological disorders.
• Disease Diagnosis: TACR2 has been implicated in several diseases, and its expression levels have been linked to disease severity. The recombinant protein can be used as an antigen in diagnostic tests to detect TACR2 levels in patient samples and aid in disease diagnosis and monitoring.
• Cell Signaling Studies: TACR2 is a GPCR that activates intracellular signaling pathways upon ligand binding. The recombinant protein can be used to study the downstream signaling events and pathways activated by TACR2, providing valuable insights into its role in various cellular processes.

Conclusion

The Recombinant Human TACR2 Protein is a synthetic version of the human TACR2 protein, produced through recombinant DNA technology. It has a similar structure and activity to the natural form and has a wide range of applications in research and therapeutics. Its ability to bind to substance P and activate downstream signaling pathways makes it a valuable tool for studying the role of TACR2 in various physiological and pathological processes.