Efungumab Biosimilar – Anti-HSP91 homolog mAb – Research Grade

Description of Efungumab Biosimilar - Anti-HSP91 homolog mAb - Research Grade

Introduction to Efungumab Biosimilar – An Anti-HSP91 Homolog mAb

Efungumab Biosimilar is a monoclonal antibody (mAb) that has been developed as a biosimilar version of the original drug, Efungumab. This antibody specifically targets the heat shock protein 90 (HSP90) homolog, which has been identified as a potential therapeutic target for various diseases. In this article, we will provide a scientific description of Efungumab Biosimilar, including its structure, activity, and potential applications.

Structure of Efungumab Biosimilar

Efungumab Biosimilar is a recombinant humanized IgG1 monoclonal antibody, with a molecular weight of approximately 150 kDa. It is composed of two identical heavy chains and two identical light chains, each containing a variable region and a constant region. The variable region of the antibody is responsible for binding to the target antigen, while the constant region plays a role in effector functions such as complement activation and antibody-dependent cellular cytotoxicity.

Activity of Efungumab Biosimilar

Efungumab Biosimilar specifically targets the HSP90 homolog, which is a highly conserved protein that plays a crucial role in cell survival and proliferation. This protein is overexpressed in many types of cancer, making it an attractive therapeutic target. By binding to the HSP90 homolog, Efungumab Biosimilar inhibits its activity, leading to the inhibition of cell growth and survival. This mechanism of action makes it a promising candidate for the treatment of various cancers.

Applications of Efungumab Biosimilar

Efungumab Biosimilar has shown promising results in preclinical studies for the treatment of various types of cancer, including breast, lung, and prostate cancer. It has also been evaluated in clinical trials for the treatment of multiple myeloma, a type of blood cancer. In addition to its potential as an anti- cancer therapy, Efungumab Biosimilar has also shown potential in the treatment of autoimmune diseases, as the HSP90 homolog has been implicated in the pathogenesis of these diseases.

Mechanism of Action of Efungumab Biosimilar

As mentioned earlier, Efungumab Biosimilar exerts its therapeutic effects by targeting the HSP90 homolog. This protein is known to play a critical role in the proper folding and stabilization of many cellular proteins, including oncogenic proteins in cancer cells. By binding to the HSP90 homolog, Efungumab Biosimilar disrupts its chaperone function, leading to the degradation of these oncogenic proteins and ultimately inhibiting the growth and survival of cancer cells.

Advantages of Efungumab Biosimilar as a Therapeutic Antibody

Efungumab Biosimilar has several advantages over other therapeutic antibodies currently available in the market. Firstly, being a biosimilar, it has a similar structure and mechanism of action to the original drug, making it a more cost-effective option. Additionally, its humanized structure reduces the risk of immunogenicity and improves its safety profile. Moreover, its high specificity for the HSP90 homolog makes it a targeted therapy, minimizing potential side effects.

Conclusion

In conclusion, Efungumab Biosimilar is a promising therapeutic antibody that specifically targets the HSP90 homolog, a protein overexpressed in many types of cancer. Its mechanism of action involves inhibiting the chaperone function of the HSP90 homolog, leading to the degradation of oncogenic proteins and inhibition of cancer cell growth. With its potential applications in various diseases and advantages as a therapeutic antibody, Efungumab Biosimilar holds great promise in the field of biopharmaceuticals.

SDS-PAGE for Efungumab Biosimilar - Anti-HSP91 homolog mAb

Efungumab Biosimilar - Anti-HSP91 homolog mAb, on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein antibody is superior than 90 %.