Ebrasodebart Biosimilar - Anti-IGFBP-3R mAb - Research Grade
Source
CAS: 2572467-73-1
Origin species
Human
Expression system
XtenCHO
Purity
>95% by SDS-PAGE
Buffer
0.01M PBS, pH 7.4
Delivery condition
Blue ice (+4°C)
Delivery lead time in business days
3-5 days if in stock; 3-5 weeks if production needed
Storage condition
4°C for short term; -20°C for long term
Brand
ProteoGenix
Aliases /Synonyms
anti-IGFBP-3R, Insulin-like growth factor-binding protein 3 receptor, TMEM219, Transmembrane protein 219
Reference
PX-TA2188-100
Note
For research use only. Not suitable for human use.
Isotype
IgG4-lambda2
Clonality
Monoclonal Antibody
Description of Ebrasodebart Biosimilar - Anti-IGFBP-3R mAb - Research Grade
Ebrasodebart Biosimilar – Anti-IGFBP-3R mAb – Research Grade: A Therapeutic Antibody Targeting IGFBP-3R
Introduction
Ebrasodebart Biosimilar – Anti-IGFBP-3R mAb – Research Grade is a novel therapeutic antibody that specifically targets insulin-like growth factor binding protein-3 receptor (IGFBP-3R). This biosimilar is designed to mimic the structure and function of the original Ebrasodebart antibody, which has shown promising results in preclinical studies for the treatment of various diseases.
Structure of Ebrasodebart Biosimilar
Ebrasodebart Biosimilar is a monoclonal antibody (mAb) that is produced through recombinant DNA technology. It is composed of two identical heavy chains and two identical light chains, with a total molecular weight of approximately 150 kDa. The antibody has a Y-shaped structure, with two antigen binding fragments (Fab) and one crystallizable fragment (Fc). The Fab region is responsible for binding to IGFBP-3R, while the Fc region is involved in effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
Mechanism of Action
IGFBP-3R is a cell surface receptor that binds to insulin-like growth factor binding protein-3 (IGFBP-3) and regulates the activity of insulin-like growth factor (IGF). Overexpression of IGFBP-3R has been linked to various diseases, including cancer, diabetes, and cardiovascular diseases. Ebrasodebart Biosimilar binds to IGFBP-3R with high affinity, preventing the interaction between IGFBP-3 and IGF. This disrupts the downstream signaling pathways involved in cell proliferation, survival, and migration, leading to inhibition of disease progression.
Applications of Ebrasodebart Biosimilar
Ebrasodebart Biosimilar has shown potential in the treatment of various diseases, including:
Cancer: IGFBP-3R is overexpressed in many types of cancer, and its inhibition has been shown to suppress tumor growth and metastasis. Ebrasodebart Biosimilar can be used as a targeted therapy for cancer, either alone or in combination with other treatments.
Diabetes: IGFBP-3R plays a role in insulin resistance, a key feature of type 2 diabetes. By blocking IGFBP-3R, Ebrasodebart Biosimilar can improve insulin sensitivity and glycemic control in diabetic patients.
Cardiovascular diseases: IGFBP-3R has been implicated in the development of atherosclerosis and other cardiovascular diseases. Ebrasodebart Biosimilar can reduce the progression of these diseases by inhibiting IGFBP-3R and its downstream effects.
Research Grade
Ebrasodebart Biosimilar – Anti-IGFBP-3R mAb – Research Grade is currently in the preclinical stage of development. Extensive research is being conducted to evaluate its safety and efficacy in various disease models. This research grade biosimilar is not yet approved for clinical use, but it shows great potential for future therapeutic applications.
Conclusion
Ebrasodebart Biosimilar – Anti-IGFBP-3R mAb – Research Grade is a promising therapeutic antibody that targets IGFBP-3R and has potential applications in cancer, diabetes,
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