4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand
ProteoGenix
Host species
Mammalian cells
Fragment Type
Met1-Asp239
Protein Accession
P14784
Reference
PX-P5555
Note
For research use only
Description of CD122 / IL2RB, C-His, recombinant protein
General information on CD122 / IL2RB, C-His, recombinant protein
CD122/IL2RB Structure
CD122, also known as Interleukin-2 Receptor Beta (IL2RB), is a type I transmembrane glycoprotein that belongs to the cytokine receptor superfamily. It is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is composed of three immunoglobulin-like domains, while the intracellular domain consists of two tyrosine-based activation motifs.
CD122/IL2RB Activity
CD122 is a receptor for Interleukin-2 (IL-2), a cytokine that plays an important role in the regulation of the immune response. The binding of IL-2 to CD122 triggers a series of intracellular signaling pathways, leading to the activation of various downstream molecules such as Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).
CD122/IL2RB Application
CD122 plays an important role in the regulation of the immune response, and its expression has been associated with various immune disorders, such as autoimmune diseases, allergies, and cancer. In addition, CD122 has been studied as a potential target for therapeutic intervention in these diseases.
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