IP-Free Humanized Mouse Models for Monoclonal Antibody Discovery

Get the high-affinity antibodies you need to advance your therapeutic project with confidence

Receive 10 high-affinity antibodies
Test where it matters most, in your samples
Advance with 3 guaranteed winners
Own every sequence. With full IP freedom

3 Guaranteed Lead Antibodies. Validated in Your Own Lab.
Fully Human. Fully Yours.

Because discovery doesn’t mean uncertainty

Receive 10 High-Affinity Antibodies

Up to 10 fully human antibodies, purified and ELISA-validated for antigen binding, with full sequence information included.

Test Where It Matters Most, In Your Samples

Test directly in your lab to identify the three top-performing antibodies under your experimental conditions.

Advance with 3 Guaranteed Winners

We guarantee three high-affinity, sequenced, and purified antibodies.
If the first panel does not fulfill the required performance, we supply additional sequences until three candidates are secured.

Own Every Sequence. With Full IP Freedom

With no royalties or licensing fees, you maintain complete control over downstream development.

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Obtain Fully Human Antibodies with Unmatched Affinity and Diversity

Harness the power of humanized mouse models combined with single B-cell screening to obtain fully human antibodies with exceptional affinity, diversity, and functionality.

Skip Affinity Maturation

Natural in vivo maturation ensures that antibodies possess therapeutic-grade affinity and specificity from the start, thereby reducing the need for optimization steps downstream.

Unlock Diversity Across Sequence, Structure & Function

Broad antibody sequence and structural repertoires through a natural immune response, reducing the risk of limited candidates or repeated sequences common in in vitro display systems.

Break Through the Challenging Targets

From GPCRs to ion channels, humanized mice generate antibodies against your most challenging targets that are difficult to target with synthetic libraries or recombinant approaches.

De-risk Your Therapeutic Pipeline

Naturally affinity-matured antibodies ensure optimal developability properties, smoothing development and regulatory paths.

Roadmap to Your First 10 Human Antibodies (8 to 11 weeks)

10 Ready-to-Test Purified Antibodies (8 to 11 weeks)
Time	4-6 weeks	2-3 weeks	2 weeks
Steps	Immunization in Proprietary Humanized Mice	Single B-Cell Screening & Validation	Recombinant Production of Up to 10 Antibodies
Description	Antigen validation by SDS-Page and immunization with our RocketAbs protocol.	PBMCs and spleen lymphocyte isolation, single B-cell sorting by FACS, B-cell cultivation, screening. Obtention of up to 30 supernatant samples.	Top clones are sequenced, and transient expression is performed. Receive 10 antibodies, purified and ELISA-validated for antigen binding, ready for direct testing in your own assays.

Keep Your Focus on Discovery, Not on IP Fees

We ensure zero royalties, zero licensing fees at every stage, from discovery to market.

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FAQs

Our humanized mouse models carry full-length human immunoglobulin gene segments (VH, Vκ, and Vλ),enabling a broad and diverse antibody repertoire. They support natural in vivo maturation, meaning the antibodies generated have high affinity, specificity, and proper folding from the start. This allows you to target even complex antigens such as GPCRs or ion channels, while ensuring that every antibody is fully human and ready for therapeutic development.
Investing in humanized mice for antibody discovery offers significant advantages over traditional methods,mainly due to their ability to generate fully human antibodies directly, eliminating the need for costly and complex humanization steps. This is crucial, especially for therapeutic development and clinical translation.
Yes. Our humanized mouse models, combined with advanced immunization strategies (including DNA,mRNA, and cell-based antigens),
allow us to tackle even the most challenging targets.
We also leverage specialized antigen presentation systems such as micelles and nanodiscs, which maintain native conformation and improve epitope accessibility. This ensures broad epitope coverage and strong,biologically relevant immune responses.
You’ll initially receive up to 10 purified, ELISA-validated antibodies ready to test in your own samples. Fromthis panel, we guarantee at least 3 validated high-affinity candidates, fully sequenced and purified, ready fordownstream development.
Your results matter to us. If the 3-antibody panel doesn’t meet your expectations, we’ll go further and identify new sequences so you always receive three functional candidates you can rely on.
You do. ProteoGenix guarantees its clients and end-to-end Freedom to Operate (FTP) when it provides its models. Sequences and antibodies are delivered with 100% ownership, with no royalties, no milestones, and no licensing restrictions. Every candidate is patent-ready from day one.

Curious if Humanized Mice Are Right for Your Research?

Book a Free Consultation with ProteoGenix Experts