Question 1

How much does antibody drug conjugation cost?

Accepted Answer

ADC conjugation typically costs a few thousand euros. Pricing depends on:

Required quantity
Antibody format
Need for antibody engineering
Whether ProteoGenix supplies the payload
Payload nature

Question 2

How long does ADC development take?

Accepted Answer

Our standard timeline ranges from 3 to 6 weeks.

Question 3

How do you ensure ADC quality?

Accepted Answer

Our QC package includes SDS-PAGE, SEC-HPLC, HIC-HPLC, and MS, providing precise control over:
DAR, DAR distribution, conjugation sites, and aggregation levels.

Question 4

Can ProteoGenix generate the starting antibody?

Accepted Answer

Absolutely. We are experts in custom antibody development and can generate your lead antibody from scratch.
For ADCs, a fully human antibody is often recommended.
We offer two dedicated discovery platforms:

Phage display service using proprietary human libraries (naive, cancer patient–derived, autoimmune patient–derived)
Single B cell screening service combined with immunization of humanized mice

We also offer off-the-shelf antibodies compatible with conjugation.

Question 5

Can you optimize an existing antibody for ADC development?

Accepted Answer

Yes! Our optimization services include:

AI-driven affinity maturation
Humanization
Developability optimization
Antibody engineering for conjugation compatibility, especially for enzymatic approaches

Question 6

Do you offer transient or stable cell line production?

Accepted Answer

Yes. ProteoGenix provides a complete continuum of recombinant expression solutions, from rapid screening to large-scale manufacturing. Our capabilities include:

A high throughput antibody production platform designed for fast candidate evaluation
A transient antibody expression service delivering milligram- to gram-scale material on short timelines
A full stable cell line development service for projects requiring long-term, scalable manufacturing

Question 7

Do you provide backup strategies if the selected format is incompatible with conjugation?

Accepted Answer

Of course. Your project’s success is our priority.
Thanks to our broad toolbox, we always propose an alternative strategy when needed.

Servicio de Conjugados Anticuerpo-Fármaco